Exhibit 23


Consent of Independent Registered Public Accounting Firm


Synergy Pharmaceuticals Inc.

New York, New York


We hereby consent to the incorporation by reference in the Registration Statements on Form S-3 (File Nos. 333-163316, 333-177730 and 333-182271) and Form S-8 (File No. 333-193349) of Synergy Pharmaceuticals Inc. and Subsidiaries (a development stage company) (the “Company”) of our reports dated March 17, 2014, relating to the consolidated financial statements and the effectiveness of the Company’s internal control over financial reporting which appear in this annual report on Form 10-K.





New York, New York



March 17, 2014